If you save a quick A/B preset while playing / rendering, it can produce _ recordable _ crackles. But saving it should not affect sound at all.
Steps to reproduce:
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Load a song with quite cpu load, put melda mrecorder in last master slot
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Put a plugin before mrecorder, for example a limiter which introduces PDC / latency
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Record the song, quick save a preset of the limiter. If you don’t hear a crackle, try other plugin
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Stop record. Check the recording, it has the crackle recorded.