Renoise became unstable since macOS 10.12 (or 10.9 even) in combination with a bunch of plugins. Those plugins work great in other DAWs, so Renoise is to blame here. I have the following best practice tips:
1. Some plugins may not load at first try (but will load on second try!, or VST version will load after loading the AU version first, e.g. Korg). In this case, place the plugins (or AU versions) into your template song. Yes, on every start of Renoise an error will appear then. But all your songs will load again afterwards.
2. Some plugins crash randomly at song load (new with 10.12.5++). Like in your template song, try to load it multiple times (here it works sometimes at 3nd try).
3. Some plugins will hang and also cause Renoise not to exit properly (since 10.9). Then enter the following into the terminal, to kill all belonging processes:
killall -m Renoise
4. Some GUIs will not open at all or do not update (e.g. TAL 32bit/no update or PSP plugins/no gui). In this case try to use the no-gui sliders. Add a remark to the plugin name like "NO GUI!!".