Use the 64bit version. Try to use 64 bit plugins only and dont use renoise's bit bridge or sandbox, a since it is a real performance hog. Keep on eye on highly optimizing vst vendors like native instruments. Often older versions of plugins perform much faster, and yes, you can create a charts hit even with old plugins. And today the hardcore programmers die out (inline assembler!!) and instead they use ugly, slow high level languages running in vms
Buy a sdd, disable spotlight for some dirs, that can speed up your Mac. Uninstall anti-virus.
Edited by ffx, 28 September 2017 - 13:56.
Test system: macOS 10.13.4, HFS+. Firewire Audio, i7 4770, 8GB Ram, GTX1050 2GB, 48kHz