Win 10 has been rock-solid for me
Same situation for me running Windows 10 (Home) on two different MSI laptops.
My newer laptop came with Windows 10 pre-installed and is kept fully up to date.
The older laptop originally came with Windows 8 pre-installed, then I later took advantage of the free upgrade to Windows 10, and is also kept up to date.
No major issues with either system, whether I'm using the on-board Realtek audio, or a really outdated external USB audio interface (American Audio Genie Pro) which is discontinued by now and doesn't even have
any drivers for Windows 10 — I actually had to use some ancient XP/Vista crap, haha.
I'm also happily using a bunch of ancient VST plugins that date back to the early 2000s in some cases, almost all of them 32-bit only and never designed with Windows 7/8/10 in mind, etc.
One thing's for sure: There are a lot of rather dodgy SynthEdit plugins lurking out there which suffer from a variety of different bugs.
Some plugins have been updated/patched after the SynthEdit dev released some fixes, while others have pretty much gone untouched for years and still have issues.
Most (if not all?) of the DSK plugins are SynthEdit, and I believe all of the Tweakbench plugs are also SynthEdit, so it wouldn't surprise me if those are behaving badly.
Sandboxing will prevent some
problems and minor instabilities from happening, but you definitely should not rely on this as a real solution.
Better to isolate each plugin one by one and figure out which ones are the real culprits, then see if any fixes/updates are available, or simply decide if it's time to retire some of them.