I’ve used Renoise exclusively on Linux for a few months now and have never had any problems.
The easiest distro I found to use (with little or no issues at all - everything just worked), was AV Linux. AV Linux is a 32 bit distro, and is fully configured with most of the applications and plugins etc you need to make music, including the realtime kernel (required to make Jack run well). My main music-making system runs AVLinux and Renoise.
I also use Renoise regularly on an Ubuntu 12.04 64bit laptop. This doesn’t have an RT kernel, but I haven’t had any problems yet. I would assume that the AV-focused version of Ubuntu - Ubuntu Studio - would probably work well for you also.
One thing to note is that it is probably easiest to use a 32 bit version of Linux - I found sometimes it was hard to find 64 bit versions of some plugins, and ended up running Renoise in 32 bit mode to get around the issue. Not ideal.
In short - I recommend AVLinux. Just works.
…both Firefox and Google Chrome on Linux can baby you with ‘autospell’ too you know
PS. there is an excellent guide to making music on Fedora Linux here. I think it makes interesting reading for all burgeoning Linux musicians, not just those using Fedora.