Let me start out by first saying that Renoise and the keyboard shortcut system is magnificent.
One thing now, I’ve grown accustomed to using Esc as Edit on/off, globally. But it’s overriding the “builtin” Esc in sample editor, which was awesome, to cut off the prehear (lil’ play button underneath SE, or plain Enter). I’m now about to make a tool that switches record/edit mode in every other renoise panel, so that I can keep using the prehear function. Maybe it should be a option by default.