Renoise 2.1 With Macbook Pro and Tascam US-1641

I’ve got a pretty strange problem with my MacBook Pro and a Tascam US-1641. All the drivers for the Tascam are installed correctly, yet to make my computer recognize the Tascam at all, I have to open the control panel for it and turn the unit on and off. If I leave the control panel open for it, it will continue to recognize it. As soon as I open Renoise, my computer and renoise will not recognize the US-1641. Kind of a strange problem, anyone have any ideas?