You catched me red-handed 
Changed to my new discovery logo.
I used ReNoise on a linux notebook for about a year and had no issues with it, and this was right when it was introduced. I haven’t used any newer versions, though. I ran Ubuntu and had Beryl installed and ReNoise cooperated with everything, even doing the whole 3D desktop stuff just fine in Beryl.
I don’t remember having to do anything special to get it to work either. It just worked.
I’m running Renoise on 64-bit Arch on a ThinkPad X200. It runs smoothly without crashes and didn’t take much effort to set up. There aren’t a lot of plug-ins but it’s not a big deal to me. I’ve got a stack of hardware synths for sampling anyway.
I mostly just use the built-in soundcard and whilst output quality is so-so (rather noisy, not very clear), latency is decent. I’m currently looking for a small Linux-friendly USB interface with a digital input and maybe 4+ outputs. I have a few nice bits of hardware noise-makers but no way of recording them, so currently I’m triggering via MIDI and mixing live on a crusty old mixer, but I’d like to bring things into Renoise to add effects; I just haven’t found the right interface.
I use Linux because for me it’s miles better for everything else that I do (consuming PDFs and writing papers with LaTeX, e-mail, web browsing, bit of coding). I can customize my working environment and do everything from the command line which is exactly how I like it.
I used to be a die-hard Ableton Live user and did the dual-boot dance for a while after switching over from a Mac, but in the end I just wasn’t making any music. Bought Renoise and whilst I’m still getting used to the switch in mentalities, I’m really very happy with it, I’ve got my hobby back, and I’m quite sure that the shortcomings in the quality and quantity of the output are my fault, not my operating system’s.