Some Weird Rendering Issues

I made a song yesterday that rendered fine the first time I rendered it. I went back to change a few things to make the mix better(turned up levels, added a few gainers, etc) and then rerendered it. It then came out crackling about 1 minute in the song, constant crackling. I found the culprit to be a plugin I was using that didnt make the sound in the xrni file. I fixed that but now when I render I get a completely blank song. Nothing like this has ever happened before