I use vanilla Ubuntu 12.10. I have a recent, fairly powerful computer. I have no complaints. Customizable it is not. Well, that’s not true, more like the remaining users of Ubuntu don’t care about this. I know Ubuntu is tweakable, I have the skills to tweak it, but I’m running this distro because I need to get shit done.
If you aren’t familiar with Linux then I have to ask why, but for me I work on this OS eight plus hours a day. It’s not all Renoise. The benefit of using Ubuntu, for me, is that all the software I need to do my job are available and I don’t have to fuck around too much.
The “bonus” is Renoise.
I have a thread about my transition here.