Audiophile 2496 - best card?

I’m buying a new machine next month and was wondering what kind of luck Audiophile owners are having with Renoise and with audio software in general. Is the latency low? Are there any compatibility issues? What do the developers recommend for use with Renoise, if not the Audiophile? Any help, as always, would be greatly appreciated.

Have a look at

M-Audio Midiport 1x1 (2x2, 2x4, 4x4, 8x8, UNO)
Opcode MIDIport 32 (96)
MOTU Fastlane
Emagic Unitor8, MT4, AMT8
Steinberg MIDEX3 (8)
Roland UM-1(S) (2, 4, 550, 880)

These are just a few of the USB(/internal) interfaces. If need be, you can opt for a serial/parallel interface.
I’ve never had to get one myself since the only controller I have is a PC-300, so I can’t vouch for them. I’ve always liked MOTU for the name though.

I use a MOTU Fastlane which works very good… USB, 2xin & 2x out, takes little space and wasn’t too expensive.

I recently bought an USB MIDI keyboard so I don’t use the interface much anymore. Direct USB or to-host cable (a cable from your sound card to your synth) gives the best result since you don’t have convert the signals to serial MIDI signals.