I think this happens with all iZotope plugins but for sure with both Neutron 3 adv and Ozone 9 adv.
Try make a basic kick track and a snare track, add Ozone or Neutron on the snare track, start playing the song, open the plugin and start clicking next preset from within the plugin and notice it’s out of sync by quite a lot. It also goes out of sync when muting the individual modules.
When you stop the song and start play it’s playing in sync.
I use latest versions of 64bit Renoise and iZotope plugs on Win 10.