I was just testing this rather new loudmax plugin which is available as a LADSPA plugin for Linux
https://www.kvraudio.com/product/loudmax-by-thomas-mundt
When I put this on the master bus or on any other track (which produces audio) there’s crackling when saving the Renoise project (and possibly also sporadically … needs to be tested).
First I thought it’s a bug in the plugin, but this happens with all LADSPA plugins.
I tested Renoise 3.0.1 and it does the same.
It happens with Jack and with ALSA. Tested on MX Linux MX-21.3_x64.