Modified clicks (CMD-click, CTRL-Click, ALT-Click, Shift-Click) for running shortcuts

hi, it would be appreciated very much if one could also bind shortcuts to modified clicks (left & right clicks). i.e. if you shift-click, ctrl-click, alt-click, cmd-click, (both left+right clicks), or use the scrollwheel, these can trigger shortcuts functions.

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I think mouse modifiers can be quite a daunting task.
REAPER allows for this somewhat, but there is so much context there.

Screencast:

Ah, but the only target here is modifier key + left mouse click, so the only context is “where to modifier key + left click”?