The tools are not running in a real-time thread, so you won’t get far when you need exact time critical responses.
If you can live with some inconsistencies, you could try that method.
Maybe this method could be used?: https://forum.renoise.com/t/automating-non-automatable-renoise-features/36368
And for stuff where timing is important one would use the Instr MIDI Control device (maybe it could also be linked to Guru somehow?).
Is this possible now? I know you can map CCs to the Guru sliders, but can any of that be recorded?