If you save a quick A/B preset while playing / rendering, it can produce _ recordable _ crackles. But saving it should not affect sound at all.
Steps to reproduce:
Load a song with quite cpu load, put melda mrecorder in last master slot
Put a plugin before mrecorder, for example a limiter which introduces PDC / latency
Record the song, quick save a preset of the limiter. If you don’t hear a crackle, try other plugin
Stop record. Check the recording, it has the crackle recorded.