When working in the sampler and after unplugging my headphone (to hear sounds through speaker), Renoise (Windows 11) seems to freeze up every time stating “Scanning for MIDI devices…”. This takes very long (1-2 minutes) and afterwards the whole program doesn’t seem to work anymore. Some menus work, but some will cause the app to freeze up again or make Renoise crash. Samples and songs won’t play back at this point. The same happens the other way around, when plugging in a headphone. Does anyone else have this problem, or better yet, a solution 
Thanks!
I’ve had a similar problem, possibly a bit more severe. When I “unplug” my airpods (putting them back into their little cozy box) with Renoise open, my system freezes completely. This is on macOS, though.
I had the same problem with my old WinXP 32bit computer a couple of years ago suddenly from one day to another (it worked fine for quite a number of years) when I still was using Renoise 2.7.2, and I couldn’t find the cause of the problem. Maybe an electricity problem, maybe an allocation problem, maybe something else. But now that I use an audio interface additionally to my soundcard on my Win10 64bit computer I never faced the same problem again.
I don’t really have a solution for your problem, but I bet if you would connect your headphones to an additional audio interface (you can get one for 99 €) you wouldn’t have this kind of problem anymore. But of course no guarantee for that.