Putting it simply and quickly:
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Renoise cannot disk-stream samples, it runs from the RAM instead. This means songs with large audio recordings are impossible (esp when you’ve only got 2gb of RAM like me). For this I have reluctantly moved to Reaper to finish these respective songs. Reaper has similar ethics and feel to Renoise, so I’m comfortable with that. I will continue to initially build my tracks in Renoise.
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Sure, we could always do with a better mixer, but Beatslaughter’s Mixer Utilities tool makes for a pretty amazing feature-set.
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I’ve used a lot of audio and music programs and I find Renoise GUI the best. Nothing’s perfect, and it would be very hard to please everyone.