I use renoise for my sample-based song bases (triphop/downtempo) and noticed that the exact same DSP chain (with external VST) sound much better when put on the TrackDSP lane than on the SampleDSP lane.
Can you render out the waveforms and compare them? Or post examples here. My guess is it may just be a volume difference causing the perception of better quality. I’ve never noticed a difference personally, and use instrument fx chains all the time
The Chain is: [Saturation] > [Compressor]
I tried to different SaturationFX with a similar result. When bypassed the Compressor acts and sounds the same. But the Saturation Plugin does compress the peaks more in the SampleDSP lane.
Track Headroom: The volume that each track’s input is lowered by. This leaves room for volume increases that may result from the use of effects, as well as helping to avoid clipping in the final mix that takes place in the Master track.
That must be the reason why I did not decrease the volume of every sample like in other DAWs.