Some VST plugin fails to load with "Instantiate FAILED (caught structured exception)". What does this mean?

Yep, it blacklists, if the plugin crashes while validation. You can edit the blacklist by using a sqlite editor. You can find the blacklist database by selecting the help menu in Renoise and then choosing “show preferences folder”. The blacklist file is named “CacheFailedPLUGINTYPExxx.db”. I usually use the freeware “DB browser for sqlite” to open it.

Or just delete the blacklist file. But don’t forget to do this while Renoise is not opened.