Working with things like NI Kontakt, I’ve often pressed Command-Z to undo a change in Kontakt…which isn’t a recognised command… so it undoes the last renoise command, which was to load an instrument.
This just happened and I lost a sampler patch I was working on completely.
Maybe if undo is going to remove an instrument like this it would be useful to have a pop-up to say “are you sure you want to remove this instrument?”
Sounds to me like something that is not supposed to happen unless Kontakt uses ctr+z as a shortcut for closing it. I’ve had similar problem in photoshop under win 10, i press a shortcut in ps and it launches a shortcut in another app. Probably not related to your problem though, but can it be that win 10 is fucking up this somehow?
If you open the plugin window, there’s a checkbox called “Enable Keyboard” at the lower left corner. If this is checked and the plugin window is focused, then your key commands should work for that plugin.