Per-song mute "presets"

If BeatSlaughter’s Mixer Utilities was upgraded for 2.8, this would be perfect for what you suggest.
In that tool, favorites are saved per song, so you don’t force yourself to some overly generic workflow.

It’s a great tool, a sort of swiss army knife for mixing. But - it’s made for 2.7 (doesn’t really work in 2.8)
With a bit of effort, I believe the script could be made to work in 2.8, and support keyboard shortcuts as well.